Jake Gyllenhaal Donnie Darko

Jena Malone Gretchen Ross

James Duval Frank

Drew Barrymore Karen Pomeroy

Beth Grant Kitty Farmer

Maggie Gyllenhaal Elizabeth Darko

Mary McDonnell Rose Darko

Holmes Osborne Eddie Darko

Noah Wyle Prof. Kenneth Monnitoff

Katharine Ross Dr. Lilian Thurman

Patrick Swayze Jim Cunningham

Daveigh Chase Samantha Darko

Arthur Taxier Dr. Fisher

David St. James Bob Garland

Patience Cleveland Roberta Sparrow / Grandma Death

Jazzie Mahannah Joanie James

Jolene Purdy Cherita Chen

David Moreland Principal Cole

Kristina Malota Susie Bates

Marina Malota Emily Bates

Scotty Leavenworth David

Phyllis Lyons Anne Fisher

Gary Lundy Sean Smith

Alex Greenwald Seth Devlin

Stuart Stone Ronald Fisher

Joan Blair Mystery Woman

Seth Rogen Ricky Danforth

Mark Hoffman Police Officer

Jerry Trainor Lanky Kid

Tom Tangen Man in Red Jogging Suit

Carly Naples Suzy Bailey

Lisa K. Wyatt Linda Connie

Rachel Winfree Shanda Riesman

Ashley Tisdale Kim

Tiler Peck Beth Farmer

Fran Kranz Passenger

Sarah Hudson Friend

Alison Jones Dorky Half-Sister

Lee Weaver Leroy

Jack Salvatore, Jr. Larry Riesman